RESEARCH DIETS

A02082002BR

特徴

A02082002BR ：
メチオニン コリン欠乏飼料（MCD飼料）、21kcal%　脂肪含有量
A02082003BY ：
メチオニン・コリン添加 コントロール飼料（MCS飼料）

詳しい配合内容についてはこちらまでお問合せください。
脂肪やメチオニン等の含有量変更、各種原料の変更などオーダーメイドも承ります。

研究領域（例）

NASH・NAFLD・脂肪肝、その他

形状

固形・粉末

使用上の注意

固形飼料：　冷凍保存推奨　週2回ほど交換推奨
粉末飼料：　冷蔵保存推奨　週2回ほど交換推奨
※成分を均一に保つ為、粉末飼料は飼料交換の都度袋の底から全体を混ぜてください。
→飼料交換回数について　リサーチダイエット社ブログより

対応動物種

マウス　ラット　ハムスター

参考論文・資料

関連情報については、お気軽にこちらよりお問合せください。

リサーチダイエット社ホームページより

NAFLD・脂肪肝のレビューはこちら　PDF

メタボリックシンドロームのレビューはこちら　PDF

  1. Eur J Pharmacol. 2006 Apr 24;536(1-2):182-91
    Tatsuya Nagasawa , Yoichi Inada, Shigeru Nakano, Toru Tamura, Tetsuaki Takahashi, Kazuyasu Maruyama, Yoshinobu Yamazaki, Junji Kuroda, Nobuo Shibata
    Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine- and
    choline-deficient diet
  2. Hepatology Research 2008; 38: 1026–1039
    Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-beta1 in a cultured stellate cell line.
    Nakano S, Nagasawa T, Ijiro T, Inada Y, Tamura T, Maruyama K, Kuroda J, Yamazaki Y, Kusama H, Shibata N.

Updated: August 12, 2013 19:20

  1. Anstee QM, Concas D, Kudo H, Levene A, Pollard J, Charlton P, Thomas HC,Thursz MR, Goldin RD. Impact of Pan-Caspase Inhibition in Animal Models of Established Steatosis and Non-Alcoholic Steatohepatitis. J Hepatol. 53:542-50. 2010.
  2. Iwamoto J, Seki A, Sato Y, Matsumoto H, Takeda T, Yeh JK. Effect of Vitamin K2 on Cortical and Cancellous Bone Mass and Hepatic Lipids in Rats with Combined Methionine-Choline Deficiency. Bone. 48:1015-21. 2011.
  3. Janevski M, Antonas KN, Sullivan-Gunn MJ, McGlynn MA, Lewandowski PA. The Effect of Cocoa Supplementation on Hepatic Steatosis, Reactive Oxygen Species and LFABP in a Rat Model of NASH. Comp Hepatol. 10:10. 2011.
  4. Kawai D, Takaki A, Nakatsuka A, Wada J, Tamaki N, Yasunaka T, Koike K, Tsuzaki R, Matsumoto K, Miyake Y, Shiraha H, Morita M, Makino H, Yamamoto K. Hydrogen-Rich Water Prevents Progression of Nonalcoholic Steatohepatitis and Accompanying Hepatocarcinogenesis in Mice. Hepatology. 56:912-21. 2012.
  5. Liao YJ, Chen TL, Lee TS, Wang HA, Wang CK, Liao LY, Liu RS, Huang SF, Chen YM. Glycine N Methyltransferase Deficiency Affects Niemann-Pick type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis. Mol Med. 18:412-22. 2012.
  6. Lloyd CM, Phillips AR, Cooper GJ, Dunbar PR. Three-Colour Fluorescence Immunohistochemistry Reveals the Diversity of Cells Staining for Macrophage Markers in Murine Spleen and Liver. J Immunol Methods. 334(1-2):70-81. 2008.
  7. Nagasawa T, Inada Y, Nakano S, Tamura T, Takahashi T, Maruyama K, Yamazaki Y, Kuroda J, Shibata N. Effects of Bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of Steatohepatitis in Mice fed a Methionine-and Choline-deficient diet. Eur J Pharmacol. 536:182-91. 2006.
  8. Nakano S, Nagasawa T, Ijiro T, Inada Y, Tamura T, Maruyama K, Kuroda J, Yamazaki Y, Kusama H, Shibata N. Bezafibrate Prevents Hepatic Stellate Cell Activation and Fibrogenesis in a Murine Steatohepatitis Model, and Suppresses Fibrogenic Response Induced by Transforming Growth Factor-Beta1 in a Cultured Stellate Cell Line. Hepatol Res. 38:1026-39. 2008.
  9. Sinclair EM, Yusta B, Streutker C, Baggio LL, Koehler J, Charron MJ, Drucker DJ. Glucagon Receptor Signaling is Essential for Control of Murine Hepatocyte Survival. Gastroenterology. 135:2096-106. 2008.

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