D12336

D12336 特徴

高脂肪高コレステロール飼料
1.25% コレステロール添加、コール酸添加、35kcal% 脂肪含有量 ココアバター・ココナツオイル使用
Paigen Dietとしても知られています。

99020201 特徴

D12336からコール酸を抜いた飼料。 1.25%コレステロール添加

コントロール飼料 D12337 特徴

0.026% コレステロール添加、コール酸無添加、10kcal% 脂肪含有量 低脂肪飼料
D12336と栄養素・カロリーなど条件を揃えたコントロール飼料

脂肪含有量やコレステロール含有量の変更、各種原料の変更などオーダーメイドも承ります。
詳しい配合内容についてはこちらまでお問合せください。

研究領域 (例)

動脈硬化、その他

形状

固形・粉末

使用上の注意

固形・粉末 どちらも常温保存可能 ※高温多湿は避けてください※
※粉末飼料の場合、成分の均一さを保つ為飼料交換の都度袋の底から全体を混ぜてください。
飼料交換回数について リサーチダイエット社ブログより

対応動物種

マウス ラット ハムスター

参考論文・資料

関連論文については、お気軽にこちらよりお申し付けください。

リサーチダイエット社ホームページより

動脈硬化のレビューはこちら PDF

メタボリックシンドロームのレビューはこちら PDF

Updated: August 12, 2013 18:46

  1. Asahina M, Mashimo T, Takeyama M, Tozawa R, Hashimoto T, Takizawa A, Ueda M, Aoto T, Kuramoto T, Serikawa T. Hypercholesterolemia and Atherosclerosis in Low Density Lipoprotein Receptor Mutant Rats. Biochem Biophys Res Commun. 418(3):553-8. 2012.
  2. Campbell IC, Weiss D, Suever JD, Virmani R, Veneziani A, Vito RP, Oshinski JN, Taylor WR. Biomechanical Modeling and Morphology Analysis Indicates Plaque Rupture Due to Mechanical Failure Unlikely in Atherosclerosis-Prone Mice. Am J Physiol Heart Circ Physiol. 304(3):H473-86. 2013
  3. Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, Porter FD. Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. Hum Mol Genet. 2006 Mar 15;15(6):839-51.
  4. Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J Biol Chem. 2005 Apr 1;280(13):12710-20.
  5. Ferrara DE, Weiss D, Carnell PH, Vito RP, Vega D, Gao X, Nie S, Taylor WR. Quantitative 3D fluorescence technique for the analysis of en face preparations of arterial walls using quantum dot nanocrystals and two-photon excitation laser scanning microscopy. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R114-23.
  6. Huang H, Liu T, Rose JL, Stevens RL, Hoyt DG. Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet.J Inflamm (Lond). 2007 Nov 12;4:22.
  7. Ivan E, Khatri JJ, Johnson C, Magid R, Godin D, Nandi S, Lessner S, Galis ZS. Expansive arterial remodeling is associated with increased neointimal macrophage foam cell content: the murine model of macrophage-rich carotid artery lesions. Circulation. 105(22):2686-91. 2002.
  8. Jääskeläinen AE, Seppälä S, Kakko T, Jaakkola U, Kallio J. Systemic Treatment with Neuropeptide Y Receptor Y1-Antagonist Enhances Atherosclerosis and Stimulates IL-12 Expression in ApoE Deficient Mice. Neuropeptides. 47:67-73. 2013
  9. Kim, SD, Hwang JK, Park SC, Kim JI, and Moon IS. Relationship of Serum Ferritin, Cholesterol, and Intimal Hyperplasia after Mechanical Injury to Carotid Artery in a Rat Model. J Korean Surg Soc. 80:131-141. 2011.
  10. Koehler K, Gordon S, Brandt P, Carlsson B, Bäcksbro-Saeidi A, Apelqvist T, Agback P, Grover GJ, Nelson W, Grynfarb M, Färnegårdh M, Rehnmark S, Malm J. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7.
  11. Lessner, S.M. Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model. American Journal of Pathology. 160:2145-2155, 2002.
  12. Lessner, S.M., et al. Compensatory vascular remodeling during atherosclerotic lesion growth depends on matrix metalloproteinase-9 activity. Arterioscler. Thromb. Vasc. Biol. 24:2123-2129, 2004.
  13. Liao YJ, Chen TL, Lee TS, Wang HA, Wang CK, Liao LY, Liu RS, Huang SF, Chen YM. Glycine N Methyltransferase Deficiency Affects Niemann-Pick type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis. Mol Med. 18:412-22. 2012.
  14. Liu W, Redmond EM, Morrow D, Cullen JP. Differential Effects of Daily-Moderate Versus Weekend-Binge Alcohol Consumption on Atherosclerotic Plaque Development in Mice. Atherosclerosis. 219:448-54. 2011.
  15. Madhur MS, Funt SA, Li L, Vinh A, Chen W, Lob HE, Iwakura Y, Blinder Y, Rahman A, Quyyumi AA, Harrison DG. Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein e-Deficient mice. Arterioscler Thromb Vasc Biol. 31:1565-72. 2011.
  16. Savoia C, Ebrahimian T, Lemarié CA, Paradis P, Iglarz M, Amiri F, Javeshgani
  17. D, Schiffrin EL. Countervailing Vascular Effects of Rosiglitazone in High Cardiovascular Risk Mice: Role of Oxidative Stress and PRMT-1. Clin Sci (Lond). 118:583-92. 2010.
  18. Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M. Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice. Biochem Biophys Res Commun. 420:72-7. 2012.
  19. Walker LC, Parker CA, Lipinski WJ, Callahan MJ, Carroll RT, Gandy SE, Smith JD, Jucker M, Bisgaier CL. Cerebral Lipid Deposition in Aged Apolipoprotein-E-Deficient Mice. Am J Pathol. 151:1371-7. 1997.
  20. Weiss D, Kools JJ, and Taylor WR. Angiotensin II-Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice. Circulation 103: 448-454, 2001.
  21. Wölle S, Via DP, Chan L, Cornicelli JA, Bisgaier CL. Hepatic Overexpression of Bovine Scavenger Receptor Type I in Transgenic Mice Prevents Diet-Induced Hyperbetalipoproteinemia. J Clin Invest. 96:260-72. 1995.
  22. Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimoto K, Doi T, Iguchi-Ariga SM, Ariga H. Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis. PLoS One. 7:e38144. 2012.

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